Sunday, 21 September 2014

GIANT - Genetic Investigation of ANthropometric Traits

Human genetics consortium number three is the GIANT - Genetic Investigation of ANthropometric Traits - consortium, a co-author of one of the recent DIAGRAM papers in Nature Genetics.

“The Genetic Investigation of ANthropometric Traits (GIANT) consortium is an international collaboration that seeks to identify genetic loci that modulate human body size and shape, including height and measures of obesity. The GIANT consortium is a collaboration between investigators from many different groups, institutions, countries, and studies, and the results represent their combined efforts. The primary approach has been meta-analysis of genome-wide association data and other large-scale genetic data sets. Anthropometric traits that have been studied by GIANT include body mass index (BMI), height, and traits related to waist circumference (such as waist-hip ratio adjusted for BMI, or WHRadjBMI). Thus far, the GIANT consortium has identified common genetic variants at hundreds of loci that are associated with anthropometric traits.”

Genome-wide association studies are big by nature, and GIANT does have a lot of participating cohorts and groups on their webpage, so I think that GIANT can be given a post hoc rating.

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